Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Connecticut | 0 | Fresno State | 45 | Final | W | 45 |
| 2 | 2021-09-04 | Fresno State | 24 | Oregon | 31 | Final | L | -7 |
| 3 | 2021-09-11 | Cal Poly | 10 | Fresno State | 63 | Final | W | 53 |
| 4 | 2021-09-18 | Fresno State | 40 | UCLA | 37 | Final | W | 3 |
| 5 | 2021-09-24 | UNLV | 30 | Fresno State | 38 | Final | W | 8 |
| 6 | 2021-10-02 | Fresno State | 24 | Hawaii | 27 | Final | L | -3 |
| 7 | 2021-10-16 | Fresno State | 17 | Wyoming | 0 | Final | W | 17 |
| 8 | 2021-10-23 | Nevada | 32 | Fresno State | 34 | Final | W | 2 |
| 9 | 2021-10-30 | Fresno State | 30 | San Diego State | 20 | Final | W | 10 |
| 10 | 2021-11-06 | Boise State | 40 | Fresno State | 14 | Final | L | -26 |
| 11 | 2021-11-13 | New Mexico | 7 | Fresno State | 34 | Final | W | 27 |
| 12 | 2021-11-25 | Fresno State (34) | 40 | San Jose State (105) | 9 | Final | W | 31 |
| 13 | 2021-12-18 | UTEP (90) | 24 | Fresno State (32) | 31 | Final | W | 7 |