Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Eastern Washington | 35 | UNLV | 33 | Final(OT) | L | -2 |
| 2 | 2021-09-11 | UNLV | 10 | Arizona State | 37 | Final | L | -27 |
| 3 | 2021-09-18 | Iowa State | 48 | UNLV | 3 | Final | L | -45 |
| 4 | 2021-09-24 | UNLV | 30 | Fresno State | 38 | Final | L | -8 |
| 5 | 2021-10-02 | UNLV | 17 | UTSA | 24 | Final | L | -7 |
| 6 | 2021-10-16 | Utah State | 28 | UNLV | 24 | Final | L | -4 |
| 7 | 2021-10-21 | San Jose State | 27 | UNLV | 20 | Final | L | -7 |
| 8 | 2021-10-29 | UNLV | 20 | Nevada | 51 | Final | L | -31 |
| 9 | 2021-11-06 | UNLV | 31 | New Mexico | 17 | Final | W | 14 |
| 10 | 2021-11-13 | Hawaii | 13 | UNLV | 27 | Final | W | 14 |
| 11 | 2021-11-20 | San Diego State | 28 | UNLV | 20 | Final | L | -8 |
| 12 | 2021-11-26 | UNLV (130) | 14 | Air Force (33) | 48 | Final | L | -34 |