Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Boise State | 31 | Central Florida | 36 | Final | L | -5 |
| 2 | 2021-09-10 | UTEP | 13 | Boise State | 54 | Final | W | 41 |
| 3 | 2021-09-18 | Oklahoma State | 21 | Boise State | 20 | Final | L | -1 |
| 4 | 2021-09-25 | Boise State | 27 | Utah State | 3 | Final | W | 24 |
| 5 | 2021-10-02 | Nevada | 41 | Boise State | 31 | Final | L | -10 |
| 6 | 2021-10-09 | Boise State | 26 | BYU | 17 | Final | W | 9 |
| 7 | 2021-10-16 | Air Force | 24 | Boise State | 17 | Final | L | -7 |
| 8 | 2021-10-30 | Boise State | 28 | Colorado State | 19 | Final | W | 9 |
| 9 | 2021-11-06 | Boise State | 40 | Fresno State | 14 | Final | W | 26 |
| 10 | 2021-11-12 | Wyoming | 13 | Boise State | 23 | Final | W | 10 |
| 11 | 2021-11-20 | New Mexico | 0 | Boise State | 37 | Final | W | 37 |
| 12 | 2021-11-26 | Boise State (32) | 16 | San Diego State (13) | 27 | Final | L | -11 |
| 13 | 2021-12-31 | Central Michigan (60) | 0 | Boise State (32) | 0 | Cancelled | - | - |