Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Fresno State | 24 | Oregon | 31 | Final | W | 7 |
| 2 | 2021-09-11 | Oregon | 35 | Ohio State | 28 | Final | W | 7 |
| 3 | 2021-09-18 | Stony Brook | 7 | Oregon | 48 | Final | W | 41 |
| 4 | 2021-09-25 | Arizona | 19 | Oregon | 41 | Final | W | 22 |
| 5 | 2021-10-02 | Oregon | 24 | Stanford | 31 | Final(OT) | L | -7 |
| 6 | 2021-10-15 | California | 17 | Oregon | 24 | Final | W | 7 |
| 7 | 2021-10-23 | Oregon | 34 | UCLA | 31 | Final | W | 3 |
| 8 | 2021-10-30 | Colorado | 29 | Oregon | 52 | Final | W | 23 |
| 9 | 2021-11-06 | Oregon | 26 | Washington | 16 | Final | W | 10 |
| 10 | 2021-11-13 | Washington State | 24 | Oregon | 38 | Final | W | 14 |
| 11 | 2021-11-20 | Oregon | 7 | Utah | 38 | Final | L | -31 |
| 12 | 2021-11-27 | Oregon State (57) | 29 | Oregon (19) | 38 | Final | W | 9 |
| 13 | 2021-12-03 | Oregon (24) | 10 | Utah (16) | 38 | Final | L | -28 |
| 14 | 2021-12-29 | Oregon (30) | 32 | Oklahoma (9) | 47 | Final | L | -15 |