Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Cal Poly | 28 | San Diego | 17 | Final | W | 11 |
| 2 | 2021-09-11 | Cal Poly | 10 | Fresno State | 63 | Final | L | -53 |
| 3 | 2021-09-18 | South Dakota | 48 | Cal Poly | 14 | Final | L | -34 |
| 4 | 2021-09-25 | Cal Poly | 7 | Montana | 39 | Final | L | -32 |
| 5 | 2021-10-02 | Weber State | 38 | Cal Poly | 7 | Final | L | -31 |
| 6 | 2021-10-09 | Cal Poly | 7 | Montana State | 45 | Final | L | -38 |
| 7 | 2021-10-23 | UC-Davis | 24 | Cal Poly | 13 | Final | L | -11 |
| 8 | 2021-10-30 | Cal Poly | 21 | Portland State | 42 | Final | L | -21 |
| 9 | 2021-11-06 | Cal Poly | 9 | Sacramento State | 41 | Final | L | -32 |
| 10 | 2021-11-13 | Idaho State | 29 | Cal Poly | 32 | Final | W | 3 |
| 11 | 2021-11-20 | Northern Arizona | 45 | Cal Poly | 21 | Final | L | -24 |