Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Nevada | 22 | California | 17 | Final | W | 5 |
| 2 | 2021-09-11 | Idaho State | 10 | Nevada | 49 | Final | W | 39 |
| 3 | 2021-09-18 | Nevada | 17 | Kansas State | 38 | Final | L | -21 |
| 4 | 2021-10-02 | Nevada | 41 | Boise State | 31 | Final | W | 10 |
| 5 | 2021-10-09 | New Mexico State | 28 | Nevada | 55 | Final | W | 27 |
| 6 | 2021-10-17 | Hawaii | 28 | Nevada | 55 | Final | W | 27 |
| 7 | 2021-10-23 | Nevada | 32 | Fresno State | 34 | Final | L | -2 |
| 8 | 2021-10-29 | UNLV | 20 | Nevada | 51 | Final | W | 31 |
| 9 | 2021-11-06 | San Jose State | 20 | Nevada | 51 | Final | W | 31 |
| 10 | 2021-11-13 | Nevada | 21 | San Diego State | 23 | Final | L | -2 |
| 11 | 2021-11-19 | Air Force | 41 | Nevada | 39 | Final(3OT) | L | -2 |
| 12 | 2021-11-27 | Nevada (39) | 52 | Colorado State (104) | 10 | Final | W | 42 |
| 13 | 2021-12-27 | Western Michigan (61) | 52 | Nevada (49) | 24 | Final | L | -28 |