Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Southern Utah | 14 | San Jose State | 45 | Final | W | 31 |
| 2 | 2021-09-04 | San Jose State | 7 | USC | 30 | Final | L | -23 |
| 3 | 2021-09-19 | San Jose State | 17 | Hawaii | 13 | Final | W | 4 |
| 4 | 2021-09-25 | San Jose State | 3 | Western Michigan | 23 | Final | L | -20 |
| 5 | 2021-10-02 | New Mexico State | 31 | San Jose State | 37 | Final | W | 6 |
| 6 | 2021-10-09 | San Jose State | 14 | Colorado State | 32 | Final | L | -18 |
| 7 | 2021-10-15 | San Diego State | 19 | San Jose State | 13 | Final(OT) | L | -6 |
| 8 | 2021-10-21 | San Jose State | 27 | UNLV | 20 | Final | W | 7 |
| 9 | 2021-10-30 | Wyoming | 21 | San Jose State | 27 | Final | W | 6 |
| 10 | 2021-11-06 | San Jose State | 20 | Nevada | 51 | Final | L | -31 |
| 11 | 2021-11-13 | Utah State | 48 | San Jose State | 17 | Final | L | -31 |
| 12 | 2021-11-25 | Fresno State (34) | 40 | San Jose State (105) | 9 | Final | L | -31 |