Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Hawaii | 10 | UCLA | 44 | Final | W | 34 |
| 2 | 2021-09-04 | LSU | 27 | UCLA | 38 | Final | W | 11 |
| 3 | 2021-09-18 | Fresno State | 40 | UCLA | 37 | Final | L | -3 |
| 4 | 2021-09-25 | UCLA | 35 | Stanford | 24 | Final | W | 11 |
| 5 | 2021-10-02 | Arizona State | 42 | UCLA | 23 | Final | L | -19 |
| 6 | 2021-10-09 | UCLA | 34 | Arizona | 16 | Final | W | 18 |
| 7 | 2021-10-16 | UCLA | 24 | Washington | 17 | Final | W | 7 |
| 8 | 2021-10-23 | Oregon | 34 | UCLA | 31 | Final | L | -3 |
| 9 | 2021-10-30 | UCLA | 24 | Utah | 44 | Final | L | -20 |
| 10 | 2021-11-13 | Colorado | 20 | UCLA | 44 | Final | W | 24 |
| 11 | 2021-11-20 | UCLA | 62 | USC | 33 | Final | W | 29 |
| 12 | 2021-11-27 | California (97) | 14 | UCLA (41) | 42 | Final | W | 28 |
| 13 | 2021-12-28 | UCLA (42) | 0 | North Carolina State (27) | 0 | Cancelled | - | - |