Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-05 | Ole Miss (4) | 34 | Florida State (12) | 45 | Final | L | -11 |
| 2 | 2016-09-10 | Wofford | 13 | Ole Miss | 38 | Final | W | 25 |
| 3 | 2016-09-17 | Alabama (1) | 48 | Ole Miss (4) | 43 | Final | L | -5 |
| 4 | 2016-09-24 | Georgia (22) | 14 | Ole Miss (94) | 45 | Final | W | 31 |
| 5 | 2016-10-01 | Memphis (19) | 28 | Ole Miss (48) | 48 | Final | W | 20 |
| 6 | 2016-10-15 | Ole Miss (26) | 30 | Arkansas (34) | 34 | Final | L | -4 |
| 7 | 2016-10-22 | Ole Miss (35) | 21 | LSU (34) | 38 | Final | L | -17 |
| 8 | 2016-10-29 | Auburn (12) | 40 | Ole Miss (50) | 29 | Final | L | -11 |
| 9 | 2016-11-05 | Georgia Southern | 27 | Ole Miss | 37 | Final | W | 10 |
| 10 | 2016-11-12 | Ole Miss (42) | 29 | Texas A&M (10) | 28 | Final | W | 1 |
| 11 | 2016-11-19 | Ole Miss (37) | 17 | Vanderbilt (75) | 38 | Final | L | -21 |
| 12 | 2016-11-26 | Mississippi State | 55 | Ole Miss | 20 | Final | L | -35 |