Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-08-27 | Charleston Southern | 17 | North Dakota State | 24 | Final/OT | L | -7 |
| 2 | 2016-09-03 | Kentucky State | 7 | Charleston Southern | 57 | Final | W | 50 |
| 3 | 2016-09-10 | Charleston Southern | 8 | Florida State | 52 | Final | L | -44 |
| 4 | 2016-09-24 | Charleston Southern | 35 | Monmouth | 7 | Final | W | 28 |
| 5 | 2016-10-01 | Charleston Southern | 59 | Coastal Carolina | 58 | Final/2OT | W | 1 |
| 6 | 2016-10-06 | Albany State | 0 | Charleston Southern | 0 | Canceled | - | - |
| 7 | 2016-10-22 | Presbyterian | 3 | Charleston Southern | 38 | Final | W | 35 |
| 8 | 2016-10-29 | Bucknell | 28 | Charleston Southern | 49 | Final | W | 21 |
| 9 | 2016-11-05 | Gardner-Webb | 17 | Charleston Southern | 10 | Final | L | -7 |
| 10 | 2016-11-12 | Charleston Southern | 48 | Liberty | 26 | Final | W | 22 |
| 11 | 2016-11-19 | Kennesaw State | 7 | Charleston Southern | 28 | Final | W | 21 |
| 12 | 2016-11-26 | Charleston Southern | 14 | Wofford | 15 | Final | L | -1 |