Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Missouri (68) | 11 | West Virginia (38) | 26 | Final | L | -15 |
| 2 | 2016-09-10 | Eastern Michigan | 21 | Missouri | 61 | Final | W | 40 |
| 3 | 2016-09-17 | Georgia (29) | 28 | Missouri (68) | 27 | Final | L | -1 |
| 4 | 2016-09-24 | Delaware State | 0 | Missouri | 79 | Final | W | 79 |
| 5 | 2016-10-01 | Missouri (44) | 7 | LSU (65) | 42 | Final | L | -35 |
| 6 | 2016-10-15 | Missouri (56) | 14 | Florida (18) | 40 | Final | L | -26 |
| 7 | 2016-10-22 | Middle Tennessee | 51 | Missouri | 45 | Final | L | -6 |
| 8 | 2016-10-29 | Kentucky (57) | 35 | Missouri (75) | 21 | Final | L | -14 |
| 9 | 2016-11-05 | Missouri (90) | 21 | South Carolina (65) | 31 | Final | L | -10 |
| 10 | 2016-11-12 | Vanderbilt (68) | 17 | Missouri (96) | 26 | Final | W | 9 |
| 11 | 2016-11-19 | Missouri (81) | 37 | Tennessee (22) | 63 | Final | L | -26 |
| 12 | 2016-11-25 | Arkansas (38) | 24 | Missouri (84) | 28 | Final | W | 4 |