Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Texas State (120) | 56 | Ohio (63) | 54 | Final/3OT | L | -2 |
| 2 | 2016-09-10 | Ohio (63) | 37 | Kansas (126) | 21 | Final | W | 16 |
| 3 | 2016-09-17 | Ohio (63) | 19 | Tennessee (18) | 28 | Final | L | -9 |
| 4 | 2016-09-24 | Gardner-Webb | 21 | Ohio | 37 | Final | W | 16 |
| 5 | 2016-10-01 | Ohio (77) | 17 | Miami (OH) (126) | 7 | Final | W | 10 |
| 6 | 2016-10-08 | Bowling Green (119) | 24 | Ohio (78) | 30 | Final | W | 6 |
| 7 | 2016-10-15 | Eastern Michigan | 27 | Ohio | 20 | Final | L | -7 |
| 8 | 2016-10-22 | Ohio (90) | 14 | Kent State (124) | 10 | Final | W | 4 |
| 9 | 2016-10-27 | Ohio (91) | 31 | Toledo (29) | 26 | Final | W | 5 |
| 10 | 2016-11-03 | Buffalo (146) | 10 | Ohio (77) | 34 | Final | W | 24 |
| 11 | 2016-11-15 | Ohio | 20 | Central Michigan | 27 | Final | L | -7 |
| 12 | 2016-11-22 | Akron (102) | 3 | Ohio (77) | 9 | Final | W | 6 |
| 13 | 2016-12-02 | Western Michigan | 29 | Ohio | 23 | Final | L | -6 |
| 14 | 2016-12-23 | Ohio (79) | 23 | Troy (44) | 28 | Final | L | -5 |