Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Mississippi Valley State | 14 | Eastern Michigan | 61 | Final | L | -47 |
| 2 | 2016-09-10 | Alabama A&M | 35 | Mississippi Valley State | 16 | Final | L | -19 |
| 3 | 2016-09-17 | Mississippi Valley State | 0 | Texas Southern | 31 | Final | L | -31 |
| 4 | 2016-09-24 | Prairie View A&M | 56 | Mississippi Valley State | 21 | Final | L | -35 |
| 5 | 2016-10-01 | Mississippi Valley State | 14 | Jackson State | 16 | Final | L | -2 |
| 6 | 2016-10-08 | Mississippi Valley State | 7 | Montana | 67 | Final | L | -60 |
| 7 | 2016-10-15 | Mississippi Valley State | 24 | Alabama State | 56 | Final | L | -32 |
| 8 | 2016-10-22 | Grambling | 59 | Mississippi Valley State | 10 | Final | L | -49 |
| 9 | 2016-11-05 | Mississippi Valley State | 41 | Arkansas-Pine Bluff | 7 | Final | W | 34 |
| 10 | 2016-11-12 | Alcorn State | 61 | Mississippi Valley State | 7 | Final | L | -54 |
| 11 | 2016-11-19 | Mississippi Valley State | 0 | Southern | 55 | Final | L | -55 |