Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Toledo (22) | 31 | Arkansas State (85) | 10 | Final | W | 21 |
| 2 | 2016-09-10 | Maine | 3 | Toledo | 45 | Final | W | 42 |
| 3 | 2016-09-17 | Fresno State (108) | 17 | Toledo (22) | 52 | Final | W | 35 |
| 4 | 2016-09-30 | Toledo (33) | 53 | BYU (81) | 55 | Final | L | -2 |
| 5 | 2016-10-08 | Toledo | 35 | Eastern Michigan | 20 | Final | W | 15 |
| 6 | 2016-10-15 | Bowling Green (121) | 35 | Toledo (35) | 42 | Final | W | 7 |
| 7 | 2016-10-22 | Central Michigan | 17 | Toledo | 31 | Final | W | 14 |
| 8 | 2016-10-27 | Ohio (91) | 31 | Toledo (29) | 26 | Final | L | -5 |
| 9 | 2016-11-02 | Toledo (45) | 48 | Akron (85) | 17 | Final | W | 31 |
| 10 | 2016-11-09 | Toledo | 31 | Northern Illinois | 24 | Final | W | 7 |
| 11 | 2016-11-16 | Ball State (114) | 19 | Toledo (42) | 37 | Final | W | 18 |
| 12 | 2016-11-25 | Toledo | 35 | Western Michigan | 55 | Final | L | -20 |
| 13 | 2016-12-17 | Appalachian State | 31 | Toledo | 28 | Final | L | -3 |