Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Army (40) | 28 | Coastal Carolina (38) | 38 | Final | W | 10 |
| 2 | 2022-09-10 | Gardner-Webb (203) | 27 | Coastal Carolina (38) | 31 | Final | W | 4 |
| 3 | 2022-09-17 | Buffalo (142) | 26 | Coastal Carolina (48) | 38 | Final | W | 12 |
| 4 | 2022-09-22 | Coastal Carolina (40) | 41 | Georgia State (145) | 24 | Final | W | 17 |
| 5 | 2022-10-01 | Georgia Southern (64) | 30 | Coastal Carolina (25) | 34 | Final | W | 4 |
| 6 | 2022-10-08 | Coastal Carolina (22) | 28 | Louisiana-Monroe (106) | 21 | Final | W | 7 |
| 7 | 2022-10-15 | Old Dominion (71) | 49 | Coastal Carolina (41) | 21 | Final | L | -28 |
| 8 | 2022-10-29 | Coastal Carolina (37) | 24 | Marshall (77) | 13 | Final | W | 11 |
| 9 | 2022-11-03 | Appalachian State (56) | 28 | Coastal Carolina (35) | 35 | Final | W | 7 |
| 10 | 2022-11-12 | Southern Miss (80) | 23 | Coastal Carolina (33) | 26 | Final | W | 3 |
| 11 | 2022-11-19 | Coastal Carolina (33) | 0 | Virginia (101) | 0 | Cancelled | - | - |
| 12 | 2022-11-26 | Coastal Carolina (49) | 7 | James Madison (35) | 47 | Final | L | -40 |
| 13 | 2022-12-03 | Coastal Carolina (57) | 26 | Troy (23) | 45 | Final | L | -19 |
| 14 | 2022-12-27 | Coastal Carolina (57) | 29 | East Carolina (65) | 53 | Final | L | -24 |