Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Virginia Tech (76) | 17 | Old Dominion (98) | 20 | Final | W | 3 |
| 2 | 2022-09-10 | Old Dominion (98) | 21 | East Carolina (62) | 39 | Final | L | -18 |
| 3 | 2022-09-17 | Old Dominion (84) | 14 | Virginia (66) | 16 | Final | L | -2 |
| 4 | 2022-09-24 | Arkansas State (107) | 26 | Old Dominion (82) | 29 | Final | W | 3 |
| 5 | 2022-10-01 | Liberty (26) | 38 | Old Dominion (90) | 24 | Final | L | -14 |
| 6 | 2022-10-15 | Old Dominion (71) | 49 | Coastal Carolina (41) | 21 | Final | W | 28 |
| 7 | 2022-10-22 | Georgia Southern (60) | 28 | Old Dominion (80) | 23 | Final | L | -5 |
| 8 | 2022-10-29 | Old Dominion (89) | 17 | Georgia State (96) | 31 | Final | L | -14 |
| 9 | 2022-11-05 | Marshall (64) | 12 | Old Dominion (98) | 0 | Final | L | -12 |
| 10 | 2022-11-12 | James Madison (52) | 37 | Old Dominion (112) | 3 | Final | L | -34 |
| 11 | 2022-11-19 | Old Dominion (118) | 14 | Appalachian State (62) | 27 | Final | L | -13 |
| 12 | 2022-11-26 | Old Dominion (121) | 20 | South Alabama (30) | 27 | Final | L | -7 |