Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | North Carolina (63) | 63 | Appalachian State (36) | 61 | Final | L | -2 |
| 2 | 2022-09-10 | Appalachian State (36) | 17 | Texas A&M (33) | 14 | Final | W | 3 |
| 3 | 2022-09-17 | Troy (94) | 28 | Appalachian State (50) | 32 | Final | W | 4 |
| 4 | 2022-09-24 | James Madison (37) | 32 | Appalachian State (27) | 28 | Final | L | -4 |
| 5 | 2022-10-01 | The Citadel (209) | 0 | Appalachian State (46) | 49 | Final | W | 49 |
| 6 | 2022-10-08 | Appalachian State (63) | 24 | Texas State (90) | 36 | Final | L | -12 |
| 7 | 2022-10-19 | Georgia State (113) | 17 | Appalachian State (51) | 42 | Final | W | 25 |
| 8 | 2022-10-20 | Georgia State (99) | 17 | Appalachian State (66) | 42 | Final | W | 25 |
| 9 | 2022-10-29 | Robert Morris (258) | 3 | Appalachian State (49) | 42 | Final | W | 39 |
| 10 | 2022-11-03 | Appalachian State (56) | 28 | Coastal Carolina (35) | 35 | Final | L | -7 |
| 11 | 2022-11-12 | Appalachian State (67) | 21 | Marshall (60) | 28 | Final | L | -7 |
| 12 | 2022-11-19 | Old Dominion (118) | 14 | Appalachian State (62) | 27 | Final | W | 13 |
| 13 | 2022-11-26 | Appalachian State (69) | 48 | Georgia Southern (77) | 51 | Final(2OT) | L | -3 |