Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Buffalo (121) | 10 | Maryland (48) | 31 | Final | L | -21 |
| 2 | 2022-09-10 | Holy Cross (139) | 37 | Buffalo (121) | 31 | Final | L | -6 |
| 3 | 2022-09-17 | Buffalo (142) | 26 | Coastal Carolina (48) | 38 | Final | L | -12 |
| 4 | 2022-09-24 | Buffalo (125) | 50 | Eastern Michigan (134) | 31 | Final | W | 19 |
| 5 | 2022-10-01 | Miami (OH) (109) | 20 | Buffalo (104) | 24 | Final | W | 4 |
| 6 | 2022-10-08 | Buffalo (86) | 38 | Bowling Green (122) | 7 | Final | W | 31 |
| 7 | 2022-10-15 | Buffalo (82) | 34 | Massachusetts (156) | 7 | Final | W | 27 |
| 8 | 2022-10-22 | Toledo (70) | 27 | Buffalo (71) | 34 | Final | W | 7 |
| 9 | 2022-11-01 | Buffalo (81) | 24 | Ohio (78) | 45 | Final | L | -21 |
| 10 | 2022-11-09 | Buffalo (91) | 27 | Central Michigan (99) | 31 | Final | L | -4 |
| 11 | 2022-11-26 | Kent State (94) | 30 | Buffalo (101) | 27 | Final(OT) | L | -3 |
| 12 | 2022-12-02 | Akron (152) | 22 | Buffalo (101) | 23 | Final | W | 1 |
| 13 | 2022-12-27 | Georgia Southern (78) | 21 | Buffalo (101) | 23 | Final | W | 2 |