Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | North Carolina State (27) | 21 | East Carolina (62) | 20 | Final | L | -1 |
| 2 | 2022-09-10 | Old Dominion (98) | 21 | East Carolina (62) | 39 | Final | W | 18 |
| 3 | 2022-09-17 | Campbell (178) | 10 | East Carolina (45) | 49 | Final | W | 39 |
| 4 | 2022-09-24 | Navy (113) | 23 | East Carolina (77) | 20 | Final(OT) | L | -3 |
| 5 | 2022-10-01 | East Carolina (71) | 48 | South Florida (132) | 28 | Final | W | 20 |
| 6 | 2022-10-08 | East Carolina (72) | 9 | Tulane (23) | 24 | Final | L | -15 |
| 7 | 2022-10-15 | Memphis (57) | 45 | East Carolina (62) | 47 | Final(4OT) | W | 2 |
| 8 | 2022-10-22 | Central Florida (36) | 13 | East Carolina (47) | 34 | Final | W | 21 |
| 9 | 2022-10-28 | East Carolina (41) | 27 | BYU (61) | 24 | Final | W | 3 |
| 10 | 2022-11-11 | East Carolina (50) | 25 | Cincinnati (29) | 27 | Final | L | -2 |
| 11 | 2022-11-19 | Houston (50) | 42 | East Carolina (63) | 3 | Final | L | -39 |
| 12 | 2022-11-26 | East Carolina (63) | 49 | Temple (134) | 46 | Final | W | 3 |
| 13 | 2022-12-27 | Coastal Carolina (57) | 29 | East Carolina (65) | 53 | Final | W | 24 |