Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Norfolk State (208) | 3 | Marshall (70) | 55 | Final | W | 52 |
| 2 | 2022-09-10 | Marshall (70) | 26 | Notre Dame (8) | 21 | Final | W | 5 |
| 3 | 2022-09-17 | Marshall (72) | 31 | Bowling Green (112) | 34 | Final(OT) | L | -3 |
| 4 | 2022-09-24 | Marshall (86) | 7 | Troy (68) | 16 | Final | L | -9 |
| 5 | 2022-10-01 | Gardner-Webb (206) | 7 | Marshall (77) | 28 | Final | W | 21 |
| 6 | 2022-10-12 | Louisiana (102) | 23 | Marshall (98) | 13 | Final | L | -10 |
| 7 | 2022-10-22 | Marshall (67) | 26 | James Madison (41) | 12 | Final | W | 14 |
| 8 | 2022-10-29 | Coastal Carolina (37) | 24 | Marshall (77) | 13 | Final | L | -11 |
| 9 | 2022-11-05 | Marshall (64) | 12 | Old Dominion (98) | 0 | Final | W | 12 |
| 10 | 2022-11-12 | Appalachian State (67) | 21 | Marshall (60) | 28 | Final | W | 7 |
| 11 | 2022-11-19 | Marshall (53) | 23 | Georgia Southern (86) | 10 | Final | W | 13 |
| 12 | 2022-11-26 | Georgia State (100) | 23 | Marshall (51) | 28 | Final | W | 5 |
| 13 | 2022-12-19 | Marshall (53) | 28 | Connecticut (99) | 14 | Final | W | 14 |