Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Alabama | 44 | Miami | 13 | Final | L | -31 |
| 2 | 2021-09-11 | Appalachian State | 23 | Miami | 25 | Final | W | 2 |
| 3 | 2021-09-18 | Michigan State | 38 | Miami | 17 | Final | L | -21 |
| 4 | 2021-09-25 | Central Connecticut State | 0 | Miami | 69 | Final | W | 69 |
| 5 | 2021-09-30 | Virginia | 30 | Miami | 28 | Final | L | -2 |
| 6 | 2021-10-16 | Miami | 42 | North Carolina | 45 | Final | L | -3 |
| 7 | 2021-10-23 | North Carolina State | 30 | Miami | 31 | Final | W | 1 |
| 8 | 2021-10-30 | Miami | 38 | Pittsburgh | 34 | Final | W | 4 |
| 9 | 2021-11-06 | Georgia Tech | 30 | Miami | 33 | Final | W | 3 |
| 10 | 2021-11-13 | Miami | 28 | Florida State | 31 | Final | L | -3 |
| 11 | 2021-11-20 | Virginia Tech | 26 | Miami | 38 | Final | W | 12 |
| 12 | 2021-11-27 | Miami (38) | 47 | Duke (135) | 10 | Final | W | 37 |