Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Southern Utah | 14 | Arizona State | 41 | Final | W | 27 |
| 2 | 2021-09-11 | UNLV | 10 | Arizona State | 37 | Final | W | 27 |
| 3 | 2021-09-18 | Arizona State | 17 | BYU | 27 | Final | L | -10 |
| 4 | 2021-09-25 | Colorado | 13 | Arizona State | 35 | Final | W | 22 |
| 5 | 2021-10-02 | Arizona State | 42 | UCLA | 23 | Final | W | 19 |
| 6 | 2021-10-08 | Stanford | 10 | Arizona State | 28 | Final | W | 18 |
| 7 | 2021-10-16 | Arizona State | 21 | Utah | 35 | Final | L | -14 |
| 8 | 2021-10-30 | Washington State | 34 | Arizona State | 21 | Final | L | -13 |
| 9 | 2021-11-06 | USC | 16 | Arizona State | 31 | Final | W | 15 |
| 10 | 2021-11-13 | Arizona State | 35 | Washington | 30 | Final | W | 5 |
| 11 | 2021-11-20 | Arizona State | 10 | Oregon State | 24 | Final | L | -14 |
| 12 | 2021-11-27 | Arizona (152) | 15 | Arizona State (48) | 38 | Final | W | 23 |
| 13 | 2021-12-30 | Wisconsin (14) | 20 | Arizona State (58) | 13 | Final | L | -7 |