Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | BYU | 24 | Arizona | 16 | Final | W | 8 |
| 2 | 2021-09-11 | Utah | 17 | BYU | 26 | Final | W | 9 |
| 3 | 2021-09-18 | Arizona State | 17 | BYU | 27 | Final | W | 10 |
| 4 | 2021-09-25 | South Florida | 27 | BYU | 35 | Final | W | 8 |
| 5 | 2021-10-01 | BYU | 34 | Utah State | 20 | Final | W | 14 |
| 6 | 2021-10-09 | Boise State | 26 | BYU | 17 | Final | L | -9 |
| 7 | 2021-10-16 | BYU | 24 | Baylor | 38 | Final | L | -14 |
| 8 | 2021-10-23 | BYU | 21 | Washington State | 19 | Final | W | 2 |
| 9 | 2021-10-30 | Virginia | 49 | BYU | 66 | Final | W | 17 |
| 10 | 2021-11-06 | Idaho State | 14 | BYU | 59 | Final | W | 45 |
| 11 | 2021-11-20 | BYU | 34 | Georgia Southern | 17 | Final | W | 17 |
| 12 | 2021-11-27 | BYU (18) | 35 | USC (86) | 31 | Final | W | 4 |
| 13 | 2021-12-18 | UAB (46) | 31 | BYU (25) | 28 | Final | L | -3 |