Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Utah State | 26 | Washington State | 23 | Final | L | -3 |
| 2 | 2021-09-11 | Portland State | 24 | Washington State | 44 | Final | W | 20 |
| 3 | 2021-09-18 | USC | 45 | Washington State | 14 | Final | L | -31 |
| 4 | 2021-09-25 | Washington State | 13 | Utah | 24 | Final | L | -11 |
| 5 | 2021-10-02 | Washington State | 21 | California | 6 | Final | W | 15 |
| 6 | 2021-10-09 | Oregon State | 24 | Washington State | 31 | Final | W | 7 |
| 7 | 2021-10-16 | Stanford | 31 | Washington State | 34 | Final | W | 3 |
| 8 | 2021-10-23 | BYU | 21 | Washington State | 19 | Final | L | -2 |
| 9 | 2021-10-30 | Washington State | 34 | Arizona State | 21 | Final | W | 13 |
| 10 | 2021-11-13 | Washington State | 24 | Oregon | 38 | Final | L | -14 |
| 11 | 2021-11-19 | Arizona | 18 | Washington State | 44 | Final | W | 26 |
| 12 | 2021-11-26 | Washington State (58) | 40 | Washington (106) | 13 | Final | W | 27 |
| 13 | 2021-12-31 | Washington State (69) | 21 | Central Michigan (60) | 24 | Final | L | -3 |