Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Montana | 13 | Washington | 7 | Final | L | -6 |
| 2 | 2021-09-11 | Washington | 10 | Michigan | 31 | Final | L | -21 |
| 3 | 2021-09-18 | Arkansas State | 3 | Washington | 52 | Final | W | 49 |
| 4 | 2021-09-25 | California | 24 | Washington | 31 | Final(OT) | W | 7 |
| 5 | 2021-10-02 | Washington | 24 | Oregon State | 27 | Final | L | -3 |
| 6 | 2021-10-16 | UCLA | 24 | Washington | 17 | Final | L | -7 |
| 7 | 2021-10-22 | Washington | 21 | Arizona | 16 | Final | W | 5 |
| 8 | 2021-10-30 | Washington | 20 | Stanford | 13 | Final | W | 7 |
| 9 | 2021-11-06 | Oregon | 26 | Washington | 16 | Final | L | -10 |
| 10 | 2021-11-13 | Arizona State | 35 | Washington | 30 | Final | L | -5 |
| 11 | 2021-11-20 | Washington | 17 | Colorado | 20 | Final | L | -3 |
| 12 | 2021-11-26 | Washington State (58) | 40 | Washington (106) | 13 | Final | L | -27 |