Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Stanford | 7 | Kansas State | 24 | Final | L | -17 |
| 2 | 2021-09-11 | Stanford | 42 | USC | 28 | Final | W | 14 |
| 3 | 2021-09-18 | Stanford | 41 | Vanderbilt | 23 | Final | W | 18 |
| 4 | 2021-09-25 | UCLA | 35 | Stanford | 24 | Final | L | -11 |
| 5 | 2021-10-02 | Oregon | 24 | Stanford | 31 | Final(OT) | W | 7 |
| 6 | 2021-10-08 | Stanford | 10 | Arizona State | 28 | Final | L | -18 |
| 7 | 2021-10-16 | Stanford | 31 | Washington State | 34 | Final | L | -3 |
| 8 | 2021-10-30 | Washington | 20 | Stanford | 13 | Final | L | -7 |
| 9 | 2021-11-05 | Utah | 52 | Stanford | 7 | Final | L | -45 |
| 10 | 2021-11-13 | Stanford | 14 | Oregon State | 35 | Final | L | -21 |
| 11 | 2021-11-20 | California | 41 | Stanford | 11 | Final | L | -30 |
| 12 | 2021-11-27 | Notre Dame (5) | 45 | Stanford (107) | 14 | Final | L | -31 |