Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Savannah State | 0 | Georgia Southern | 54 | Final | W | 54 |
| 2 | 2016-09-10 | Georgia Southern | 24 | South Alabama | 9 | Final | W | 15 |
| 3 | 2016-09-17 | Louisiana-Monroe | 21 | Georgia Southern | 23 | Final | W | 2 |
| 4 | 2016-09-24 | Georgia Southern | 31 | Western Michigan | 49 | Final | L | -18 |
| 5 | 2016-10-05 | Georgia Southern | 26 | Arkansas State | 27 | Final | L | -1 |
| 6 | 2016-10-15 | Georgia Southern | 24 | Georgia Tech | 35 | Final | L | -11 |
| 7 | 2016-10-22 | Georgia Southern | 22 | New Mexico State | 19 | Final | W | 3 |
| 8 | 2016-10-27 | Appalachian State | 34 | Georgia Southern | 10 | Final | L | -24 |
| 9 | 2016-11-05 | Georgia Southern | 27 | Ole Miss | 37 | Final | L | -10 |
| 10 | 2016-11-10 | Louisiana | 33 | Georgia Southern | 26 | Final | L | -7 |
| 11 | 2016-11-19 | Georgia Southern | 24 | Georgia State | 30 | Final | L | -6 |
| 12 | 2016-12-03 | Troy | 24 | Georgia Southern | 28 | Final | W | 4 |