Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Southern | 21 | Louisiana-Monroe | 38 | Final | W | 17 |
| 2 | 2016-09-10 | Louisiana-Monroe | 17 | Oklahoma | 59 | Final | L | -42 |
| 3 | 2016-09-17 | Louisiana-Monroe | 21 | Georgia Southern | 23 | Final | L | -2 |
| 4 | 2016-10-01 | Louisiana-Monroe | 7 | Auburn | 58 | Final | L | -51 |
| 5 | 2016-10-08 | Idaho | 34 | Louisiana-Monroe | 31 | Final | L | -3 |
| 6 | 2016-10-15 | Texas State | 34 | Louisiana-Monroe | 40 | Final | W | 6 |
| 7 | 2016-10-22 | Louisiana-Monroe | 17 | New Mexico | 59 | Final | L | -42 |
| 8 | 2016-10-29 | Louisiana-Monroe | 10 | Arkansas State | 51 | Final | L | -41 |
| 9 | 2016-11-05 | South Alabama | 35 | Louisiana-Monroe | 42 | Final/OT | W | 7 |
| 10 | 2016-11-12 | Louisiana-Monroe | 37 | Georgia State | 23 | Final | W | 14 |
| 11 | 2016-11-19 | Louisiana-Monroe | 17 | Appalachian State | 42 | Final | L | -25 |
| 12 | 2016-12-03 | Louisiana | 30 | Louisiana-Monroe | 3 | Final | L | -27 |