Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Brescia | 0 | 0 | Murray State (116) | Cancelled | - | - |
| 2 | 2020-11-25 | Brescia | Murray State (136) | Cancelled | - | - | ||
| 3 | 2020-11-27 | Kentucky Wesleyan | 0 | 0 | Murray State (116) | Cancelled | - | - |
| 4 | 2020-11-27 | Kentucky Wesleyan | Murray State (136) | Cancelled | - | - | ||
| 5 | 2020-11-28 | Kentucky Wesleyan | 0 | 0 | Murray State (116) | Cancelled | - | - |
| 6 | 2020-11-28 | Kentucky Wesleyan | Murray State (136) | Cancelled | - | - | ||
| 7 | 2020-11-29 | Greenville | 95 | 173 | Murray State (116) | Final | W | 78 |
| 8 | 2020-12-02 | Murray State (116) | 61 | 78 | Middle Tennessee (164) | Final | L | -17 |
| 9 | 2020-12-05 | Illinois State (94) | 65 | 76 | Murray State (116) | Final | W | 11 |
| 10 | 2020-12-08 | Austin Peay (138) | 57 | 87 | Murray State (116) | Final | W | 30 |
| 11 | 2020-12-11 | Murray State (116) | 66 | 70 | Southern Illinois (150) | Final | L | -4 |
| 12 | 2020-12-15 | Prairie View A&M (226) | Murray State (108) | Cancelled | - | - | ||
| 13 | 2020-12-15 | Transylvania | 49 | 90 | Murray State (116) | Final | W | 41 |
| 14 | 2020-12-21 | Murray State (116) | 70 | 74 | Austin Peay (138) | Final | L | -4 |
| 15 | 2020-12-30 | Murray State (116) | 55 | 68 | Belmont (68) | Final | L | -13 |
| 16 | 2021-01-02 | Morehead State (233) | 61 | 56 | Murray State (116) | Final | L | -5 |
| 17 | 2021-01-07 | Murray State (116) | 68 | 74 | Eastern Illinois (314) | Final | L | -6 |
| 18 | 2021-01-09 | Murray State (116) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 19 | 2021-01-14 | Murray State (116) | 0 | 0 | Southeast Missouri State (226) | Cancelled | - | - |
| 20 | 2021-01-16 | Murray State (116) | 79 | 57 | Tennessee-Martin (205) | Final | W | 22 |
| 21 | 2021-01-21 | Jacksonville State (227) | 85 | 82 | Murray State (116) | Final | L | -3 |
| 22 | 2021-01-23 | Tennessee Tech (310) | 63 | 72 | Murray State (116) | Final | W | 9 |
| 23 | 2021-01-28 | Tennessee State (165) | 53 | 73 | Murray State (116) | Final | W | 20 |
| 24 | 2021-01-30 | Belmont (68) | 72 | 71 | Murray State (116) | Final | L | -1 |
| 25 | 2021-02-01 | Murray State (116) | 77 | 60 | Southeast Missouri State (226) | Final | W | 17 |
| 26 | 2021-02-04 | Murray State (116) | 56 | 66 | Morehead State (233) | Final | L | -10 |
| 27 | 2021-02-06 | Murray State (116) | 76 | 64 | Eastern Kentucky (288) | Final | W | 12 |
| 28 | 2021-02-09 | Murray State (116) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 29 | 2021-02-12 | Southeast Missouri State (226) | 60 | 80 | Murray State (116) | Final | W | 20 |
| 30 | 2021-02-13 | Tennessee-Martin (205) | 55 | 84 | Murray State (116) | Final | W | 29 |
| 31 | 2021-02-15 | Murray State (116) | 86 | 57 | SIU-Edwardsville (248) | Final | W | 29 |
| 32 | 2021-02-18 | Eastern Illinois (314) | 68 | 59 | Murray State (116) | Final | L | -9 |
| 33 | 2021-02-20 | SIU-Edwardsville (248) | 62 | 89 | Murray State (116) | Final | W | 27 |
| 34 | 2021-02-25 | Murray State (116) | 74 | 87 | Jacksonville State (227) | Final | L | -13 |
| 35 | 2021-02-27 | Murray State (116) | 61 | 71 | Tennessee Tech (310) | Final | L | -10 |
| 36 | 2021-03-04 | Murray State (116) | 65 | 68 | Jacksonville State (227) | Final/OT | L | -3 |