Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Southeast Missouri State (342) | Northern Colorado (106) | Cancelled | - | - | ||
| 2 | 2020-11-28 | Southeast Missouri State (226) | 71 | 66 | UMKC (364) | Final | W | 5 |
| 3 | 2020-11-29 | Greenville | Southeast Missouri State (342) | Cancelled | - | - | ||
| 4 | 2020-12-02 | Southern Illinois (150) | 87 | 79 | Southeast Missouri State (226) | Final/OT | L | -8 |
| 5 | 2020-12-07 | Lipscomb (190) | 77 | 82 | Southeast Missouri State (226) | Final | W | 5 |
| 6 | 2020-12-09 | Southeast Missouri State (226) | 74 | 80 | Lipscomb (190) | Final/OT | L | -6 |
| 7 | 2020-12-12 | Southeast Missouri State (226) | 0 | 0 | Tennessee-Martin (205) | Postponed | - | - |
| 8 | 2020-12-15 | Southeast Missouri State (226) | 63 | 66 | Evansville (302) | Final/OT | L | -3 |
| 9 | 2020-12-18 | Tennessee-Martin (205) | 69 | 67 | Southeast Missouri State (226) | Final | L | -2 |
| 10 | 2020-12-22 | Southeast Missouri State (226) | 66 | 72 | Indiana State (243) | Final | L | -6 |
| 11 | 2020-12-30 | Southeast Missouri State (226) | 63 | 72 | Tennessee Tech (310) | Final | L | -9 |
| 12 | 2021-01-02 | Tennessee State (165) | 79 | 83 | Southeast Missouri State (226) | Final/2OT | W | 4 |
| 13 | 2021-01-07 | Southeast Missouri State (226) | 66 | 77 | Belmont (68) | Final | L | -11 |
| 14 | 2021-01-11 | Southeast Missouri State (226) | 0 | 0 | Tennessee-Martin (205) | Postponed | - | - |
| 15 | 2021-01-14 | Murray State (116) | 0 | 0 | Southeast Missouri State (226) | Cancelled | - | - |
| 16 | 2021-01-16 | Morehead State (233) | 64 | 50 | Southeast Missouri State (226) | Final | L | -14 |
| 17 | 2021-01-19 | Southeast Missouri State (226) | 63 | 59 | Tennessee State (165) | Final | W | 4 |
| 18 | 2021-01-21 | Southeast Missouri State (226) | 65 | 76 | Morehead State (233) | Final | L | -11 |
| 19 | 2021-01-23 | Southeast Missouri State (226) | 0 | 0 | Eastern Kentucky (288) | Cancelled | - | - |
| 20 | 2021-01-26 | Southeast Missouri State (226) | 66 | 69 | Tennessee-Martin (205) | Final | L | -3 |
| 21 | 2021-01-28 | SIU-Edwardsville (248) | 62 | 64 | Southeast Missouri State (226) | Final | W | 2 |
| 22 | 2021-01-30 | Eastern Illinois (314) | 44 | 75 | Southeast Missouri State (226) | Final | W | 31 |
| 23 | 2021-02-01 | Murray State (116) | 77 | 60 | Southeast Missouri State (226) | Final | L | -17 |
| 24 | 2021-02-04 | Tennessee Tech (310) | 64 | 68 | Southeast Missouri State (226) | Final | W | 4 |
| 25 | 2021-02-06 | Jacksonville State (227) | 66 | 54 | Southeast Missouri State (226) | Final | L | -12 |
| 26 | 2021-02-12 | Southeast Missouri State (226) | 60 | 80 | Murray State (116) | Final | L | -20 |
| 27 | 2021-02-13 | Southeast Missouri State (226) | 63 | 78 | Austin Peay (138) | Final | L | -15 |
| 28 | 2021-02-16 | Austin Peay (138) | 81 | 86 | Southeast Missouri State (226) | Final/OT | W | 5 |
| 29 | 2021-02-19 | Morehead State (233) | 0 | 0 | Southeast Missouri State (226) | Cancelled | - | - |
| 30 | 2021-02-20 | Eastern Kentucky (288) | 72 | 94 | Southeast Missouri State (226) | Final | W | 22 |
| 31 | 2021-02-22 | Eastern Kentucky (288) | 87 | 65 | Southeast Missouri State (226) | Final | L | -22 |
| 32 | 2021-02-25 | Southeast Missouri State (226) | 94 | 88 | Eastern Illinois (314) | Final | W | 6 |
| 33 | 2021-02-27 | Southeast Missouri State (226) | 69 | 63 | SIU-Edwardsville (248) | Final | W | 6 |
| 34 | 2021-03-03 | Southeast Missouri State (226) | 54 | 61 | Morehead State (233) | Final | L | -7 |