Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Jacksonville State (227) | 57 | 81 | Alabama (15) | Final | L | -24 |
| 2 | 2020-11-27 | Jacksonville State (227) | 60 | 50 | Florida Atlantic (128) | Final | W | 10 |
| 3 | 2020-11-29 | Jacksonville State (227) | 77 | 73 | South Alabama (177) | Final | W | 4 |
| 4 | 2020-11-30 | Mobile | 66 | 85 | Jacksonville State (227) | Final | W | 19 |
| 5 | 2020-12-04 | Jacksonville State (227) | 70 | 74 | Florida International (214) | Final | L | -4 |
| 6 | 2020-12-06 | Jacksonville State (227) | 0 | 0 | Florida International (214) | Cancelled | - | - |
| 7 | 2020-12-13 | Jacksonville State (227) | 73 | 67 | Tennessee Tech (310) | Final | W | 6 |
| 8 | 2020-12-16 | Tennessee Tech (310) | 50 | 74 | Jacksonville State (227) | Final | W | 24 |
| 9 | 2020-12-18 | Georgia Southwestern | 0 | 0 | Jacksonville State (227) | Cancelled | - | - |
| 10 | 2020-12-27 | Carver Bible | 45 | 104 | Jacksonville State (187) | Final | W | 59 |
| 11 | 2020-12-30 | Tennessee-Martin (205) | 70 | 80 | Jacksonville State (227) | Final | W | 10 |
| 12 | 2021-01-02 | Jacksonville State (227) | 0 | 0 | SIU-Edwardsville (248) | Cancelled | - | - |
| 13 | 2021-01-07 | Jacksonville State (227) | 66 | 69 | Eastern Kentucky (288) | Final/OT | L | -3 |
| 14 | 2021-01-09 | Jacksonville State (227) | 55 | 56 | Morehead State (233) | Final | L | -1 |
| 15 | 2021-01-14 | Tennessee State (165) | 64 | 65 | Jacksonville State (227) | Final | W | 1 |
| 16 | 2021-01-16 | Belmont (68) | 98 | 91 | Jacksonville State (227) | Final | L | -7 |
| 17 | 2021-01-18 | Jacksonville State (227) | 0 | 0 | SIU-Edwardsville (248) | Cancelled | - | - |
| 18 | 2021-01-21 | Jacksonville State (227) | 85 | 82 | Murray State (116) | Final | W | 3 |
| 19 | 2021-01-23 | Jacksonville State (227) | 76 | 70 | Austin Peay (138) | Final | W | 6 |
| 20 | 2021-01-28 | Morehead State (233) | 85 | 66 | Jacksonville State (227) | Final | L | -19 |
| 21 | 2021-01-30 | Eastern Kentucky (288) | 0 | 0 | Jacksonville State (227) | Postponed | - | - |
| 22 | 2021-02-02 | Eastern Kentucky (288) | 86 | 82 | Jacksonville State (227) | Final/OT | L | -4 |
| 23 | 2021-02-04 | Jacksonville State (227) | 82 | 70 | Tennessee-Martin (205) | Final | W | 12 |
| 24 | 2021-02-06 | Jacksonville State (227) | 66 | 54 | Southeast Missouri State (226) | Final | W | 12 |
| 25 | 2021-02-11 | Eastern Illinois (314) | 64 | 76 | Jacksonville State (227) | Final | W | 12 |
| 26 | 2021-02-13 | SIU-Edwardsville (248) | 60 | 80 | Jacksonville State (227) | Final | W | 20 |
| 27 | 2021-02-18 | Jacksonville State (227) | 59 | 63 | Belmont (68) | Final | L | -4 |
| 28 | 2021-02-20 | Jacksonville State (227) | 77 | 76 | Tennessee State (165) | Final | W | 1 |
| 29 | 2021-02-25 | Murray State (116) | 74 | 87 | Jacksonville State (227) | Final | W | 13 |
| 30 | 2021-02-27 | Austin Peay (138) | 67 | 75 | Jacksonville State (227) | Final | W | 8 |
| 31 | 2021-03-04 | Murray State (116) | 65 | 68 | Jacksonville State (227) | Final/OT | W | 3 |
| 32 | 2021-03-05 | Jacksonville State (227) | 69 | 72 | Belmont (68) | Final | L | -3 |