NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Detroit (327) | 40 | 63 | Loyola-Chicago (160) | Final | L | -23 |
| 2 | 2021-11-13 | Detroit (327) | 66 | 76 | Eastern Michigan (154) | Final | L | -10 |
| 3 | 2021-11-18 | Robert Morris (215) | 55 | 46 | Detroit (320) | Final | L | -9 |
| 4 | 2021-11-20 | Youngstown State (51) | 64 | 56 | Detroit (342) | Final | L | -8 |
| 5 | 2021-11-23 | Detroit (320) | 55 | 64 | Canisius (347) | Final | L | -9 |
| 6 | 2021-11-29 | Detroit (337) | 60 | 67 | Akron (149) | Final | L | -7 |
| 7 | 2021-12-02 | IUPUI (100) | 87 | 52 | Detroit (348) | Final | L | -35 |
| 8 | 2021-12-04 | Illinois-Chicago (201) | 68 | 64 | Detroit (320) | Final/OT | L | -4 |
| 9 | 2021-12-08 | Western Michigan (140) | 58 | 51 | Detroit (350) | Final | L | -7 |
| 10 | 2021-12-18 | North Dakota (332) | 70 | 60 | Detroit (320) | Final | L | -10 |
| 11 | 2021-12-21 | Detroit (349) | 57 | 69 | Valparaiso (337) | Final | L | -12 |
| 12 | 2021-12-30 | Detroit (351) | 0 | 0 | Green Bay (159) | Forfeit | - | - |
| 13 | 2022-01-01 | Detroit (351) | 0 | 0 | Milwaukee (227) | Forfeit | - | - |
| 14 | 2022-01-06 | Detroit (350) | 0 | 0 | Cleveland State (171) | Canceled | - | - |
| 15 | 2022-01-08 | Detroit (320) | 57 | 62 | Purdue Fort Wayne (148) | Final | L | -5 |
| 16 | 2022-01-13 | Northern Kentucky (193) | 74 | 54 | Detroit (320) | Final | L | -20 |
| 17 | 2022-01-15 | Wright State (324) | 72 | 56 | Detroit (352) | Final | L | -16 |
| 18 | 2022-01-20 | Detroit (354) | 50 | 80 | Oakland (208) | Final | L | -30 |
| 19 | 2022-01-22 | Oakland (208) | 66 | 62 | Detroit (354) | Final | L | -4 |
| 20 | 2022-01-28 | Detroit (354) | 59 | 78 | Youngstown State (99) | Final | L | -19 |
| 21 | 2022-01-30 | Detroit (354) | 56 | 68 | Robert Morris (282) | Final | L | -12 |
| 22 | 2022-02-04 | Detroit (355) | 0 | 0 | Illinois-Chicago (339) | Postponed | - | - |
| 23 | 2022-02-06 | Detroit (355) | 49 | 66 | IUPUI (61) | Final | L | -17 |
| 24 | 2022-02-10 | Milwaukee (318) | 71 | 55 | Detroit (320) | Final | L | -16 |
| 25 | 2022-02-12 | Green Bay (109) | 53 | 39 | Detroit (355) | Final | L | -14 |
| 26 | 2022-02-14 | Detroit (355) | 63 | 61 | Illinois-Chicago (340) | Final | W | 2 |
| 27 | 2022-02-17 | Purdue Fort Wayne (326) | 77 | 62 | Detroit (351) | Final | L | -15 |
| 28 | 2022-02-19 | Cleveland State (174) | 74 | 70 | Detroit (351) | Final | L | -4 |
| 29 | 2022-02-21 | Cleveland State (174) | 80 | 60 | Detroit (351) | Final | L | -20 |
| 30 | 2022-02-24 | Detroit (352) | 67 | 71 | Wright State (334) | Final | L | -4 |
| 31 | 2022-02-26 | Detroit (352) | 44 | 67 | Northern Kentucky (139) | Final | L | -23 |
| 32 | 2022-03-01 | Detroit (353) | 50 | 73 | Northern Kentucky (135) | Final | L | -23 |