NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | UMKC (237) | 63 | 75 | SMU (284) | Final | W | 12 |
| 2 | 2021-11-14 | Oklahoma State (26) | 67 | 50 | SMU (284) | Final | L | -17 |
| 3 | 2021-11-17 | Oral Roberts (273) | 44 | 81 | SMU (180) | Final | W | 37 |
| 4 | 2021-11-22 | SMU (180) | 58 | 65 | Arkansas (97) | Final | L | -7 |
| 5 | 2021-11-25 | Seattle (343) | 70 | 66 | SMU (209) | Final | L | -4 |
| 6 | 2021-11-27 | SMU (106) | 53 | 43 | Green Bay (231) | Final | W | 10 |
| 7 | 2021-11-30 | Oklahoma (40) | 84 | 72 | SMU (106) | Final | L | -12 |
| 8 | 2021-12-03 | SMU (106) | 58 | 84 | North Texas (138) | Final | L | -26 |
| 9 | 2021-12-07 | Delaware (112) | 55 | 61 | SMU (136) | Final | W | 6 |
| 10 | 2021-12-17 | SMU (119) | 55 | 78 | Colorado (23) | Final | L | -23 |
| 11 | 2021-12-21 | Texas-Arlington (76) | 0 | 0 | SMU (133) | Cancelled | - | - |
| 12 | 2021-12-28 | Arkansas-Pine Bluff (306) | 74 | 86 | SMU (209) | Final | W | 12 |
| 13 | 2022-01-01 | East Carolina (164) | 0 | 0 | SMU (134) | Postponed | - | - |
| 14 | 2022-01-02 | SMU (209) | 79 | 53 | TCU (12) | Final | W | 26 |
| 15 | 2022-01-05 | SMU (209) | 0 | 0 | Temple (151) | Postponed | - | - |
| 16 | 2022-01-08 | SMU (209) | 63 | 44 | Memphis (239) | Final | W | 19 |
| 17 | 2022-01-13 | East Carolina (106) | 49 | 60 | SMU (209) | Final | W | 11 |
| 18 | 2022-01-15 | Tulane (92) | 62 | 67 | SMU (104) | Final/OT | W | 5 |
| 19 | 2022-01-19 | Central Florida (150) | 0 | 0 | SMU (209) | Postponed | - | - |
| 20 | 2022-01-22 | SMU (86) | 0 | 0 | Tulsa (93) | Postponed | - | - |
| 21 | 2022-01-26 | South Florida (32) | 62 | 56 | SMU (89) | Final | L | -6 |
| 22 | 2022-02-03 | SMU (87) | 58 | 46 | East Carolina (193) | Final | W | 12 |
| 23 | 2022-02-06 | Houston (96) | 60 | 55 | SMU (87) | Final | L | -5 |
| 24 | 2022-02-09 | SMU (209) | 71 | 66 | Cincinnati (122) | Final | W | 5 |
| 25 | 2022-02-12 | SMU (92) | 47 | 58 | Wichita State (126) | Final | L | -11 |
| 26 | 2022-02-16 | Memphis (239) | 72 | 54 | SMU (209) | Final | L | -18 |
| 27 | 2022-02-19 | SMU (94) | 75 | 42 | Tulsa (107) | Final | W | 33 |
| 28 | 2022-02-23 | SMU (95) | 58 | 67 | Tulane (59) | Final | L | -9 |
| 29 | 2022-02-26 | SMU (95) | 36 | 65 | Houston (88) | Final | L | -29 |
| 30 | 2022-02-28 | Temple (99) | 61 | 65 | SMU (95) | Final/OT | W | 4 |
| 31 | 2022-03-02 | Temple (109) | 56 | 48 | SMU (97) | Final | L | -8 |
| 32 | 2022-03-08 | SMU (100) | 63 | 55 | Temple (104) | Final | W | 8 |
| 33 | 2022-03-09 | SMU (100) | 28 | 61 | Central Florida (16) | Final | L | -33 |
| 34 | 2022-03-17 | Tennessee Tech (142) | 73 | 62 | SMU (100) | Final | L | -11 |