NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Howard (127) | 48 | 80 | Houston (42) | Final | W | 32 |
| 2 | 2021-11-12 | Houston (180) | 52 | 73 | Stephen F. Austin (159) | Final | L | -21 |
| 3 | 2021-11-17 | Houston (175) | 66 | 69 | Texas-Arlington (191) | Final/OT | L | -3 |
| 4 | 2021-11-20 | New Mexico (72) | 60 | 89 | Houston (175) | Final | W | 29 |
| 5 | 2021-11-25 | Arizona State (46) | 60 | 68 | Houston (180) | Final | W | 8 |
| 6 | 2021-11-26 | Houston (180) | 53 | 67 | Fordham (261) | Final | L | -14 |
| 7 | 2021-11-27 | Baylor (54) | 74 | 58 | Houston (120) | Final | L | -16 |
| 8 | 2021-12-03 | Houston (121) | 67 | 77 | Alabama (60) | Final | L | -10 |
| 9 | 2021-12-09 | Jacksonville State (145) | 65 | 72 | Houston (107) | Final | W | 7 |
| 10 | 2021-12-12 | Louisiana (127) | 51 | 63 | Houston (107) | Final | W | 12 |
| 11 | 2021-12-16 | Houston (94) | 78 | 68 | Florida State (90) | Final | W | 10 |
| 12 | 2021-12-21 | Texas A&M-Corpus Christi (260) | 51 | 78 | Houston (87) | Final | W | 27 |
| 13 | 2021-12-29 | Southeastern Louisiana (262) | 0 | 0 | Houston (76) | Cancelled | - | - |
| 14 | 2022-01-02 | Tulane (211) | 0 | 0 | Houston (180) | Postponed | - | - |
| 15 | 2022-01-05 | Houston (180) | 66 | 61 | Wichita State (266) | Final | W | 5 |
| 16 | 2022-01-08 | Tulsa (140) | 67 | 80 | Houston (180) | Final | W | 13 |
| 17 | 2022-01-11 | Houston (64) | 59 | 62 | Central Florida (24) | Final | L | -3 |
| 18 | 2022-01-15 | Houston (64) | 54 | 62 | Temple (134) | Final | L | -8 |
| 19 | 2022-01-17 | Tulane (92) | 64 | 59 | Houston (64) | Final | L | -5 |
| 20 | 2022-01-19 | Cincinnati (122) | 71 | 56 | Houston (180) | Final | L | -15 |
| 21 | 2022-01-22 | Houston (82) | 53 | 57 | Memphis (111) | Final | L | -4 |
| 22 | 2022-01-30 | South Florida (32) | 55 | 35 | Houston (98) | Final | L | -20 |
| 23 | 2022-02-02 | Houston (96) | 65 | 64 | Tulsa (95) | Final | W | 1 |
| 24 | 2022-02-06 | Houston (96) | 60 | 55 | SMU (87) | Final | W | 5 |
| 25 | 2022-02-09 | Central Florida (150) | 54 | 44 | Houston (180) | Final | L | -10 |
| 26 | 2022-02-16 | East Carolina (106) | 55 | 67 | Houston (180) | Final | W | 12 |
| 27 | 2022-02-20 | Houston (90) | 72 | 76 | Tulane (64) | Final | L | -4 |
| 28 | 2022-02-23 | Temple (99) | 60 | 80 | Houston (88) | Final | W | 20 |
| 29 | 2022-02-26 | SMU (95) | 36 | 65 | Houston (88) | Final | W | 29 |
| 30 | 2022-03-02 | Houston (81) | 38 | 71 | South Florida (36) | Final | L | -33 |
| 31 | 2022-03-07 | Cincinnati (177) | 45 | 67 | Houston (81) | Final | W | 22 |
| 32 | 2022-03-08 | Houston (79) | 65 | 57 | Tulane (59) | Final | W | 8 |
| 33 | 2022-03-09 | Houston (79) | 50 | 58 | South Florida (34) | Final | L | -8 |
| 34 | 2022-03-17 | Houston (79) | 63 | 52 | Louisiana Tech (129) | Final | W | 11 |
| 35 | 2022-03-20 | Tennessee Tech (142) | 55 | 63 | Houston (79) | Final | W | 8 |
| 36 | 2022-03-24 | Houston (79) | 64 | 79 | Alabama (54) | Final | L | -15 |