Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-03 | North Carolina | 10 | Virginia Tech | 17 | Final | L | -7 |
| 2 | 2021-09-11 | Georgia State | 17 | North Carolina | 59 | Final | W | 42 |
| 3 | 2021-09-18 | Virginia | 39 | North Carolina | 59 | Final | W | 20 |
| 4 | 2021-09-25 | North Carolina | 22 | Georgia Tech | 45 | Final | L | -23 |
| 5 | 2021-10-02 | Duke | 7 | North Carolina | 38 | Final | W | 31 |
| 6 | 2021-10-09 | Florida State | 35 | North Carolina | 25 | Final | L | -10 |
| 7 | 2021-10-16 | Miami | 42 | North Carolina | 45 | Final | W | 3 |
| 8 | 2021-10-30 | North Carolina | 34 | Notre Dame | 44 | Final | L | -10 |
| 9 | 2021-11-06 | Wake Forest | 55 | North Carolina | 58 | Final | W | 3 |
| 10 | 2021-11-11 | North Carolina | 23 | Pittsburgh | 30 | Final(OT) | L | -7 |
| 11 | 2021-11-20 | Wofford | 14 | North Carolina | 34 | Final | W | 20 |
| 12 | 2021-11-26 | North Carolina (53) | 30 | North Carolina State (27) | 34 | Final | L | -4 |
| 13 | 2021-12-30 | North Carolina (63) | 21 | South Carolina (56) | 38 | Final | L | -17 |