Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Central Arkansas | 21 | Arkansas State | 40 | Final | W | 19 |
| 2 | 2021-09-11 | Memphis | 55 | Arkansas State | 50 | Final | L | -5 |
| 3 | 2021-09-18 | Arkansas State | 3 | Washington | 52 | Final | L | -49 |
| 4 | 2021-09-25 | Arkansas State | 34 | Tulsa | 41 | Final | L | -7 |
| 5 | 2021-10-02 | Arkansas State | 33 | Georgia Southern | 59 | Final | L | -26 |
| 6 | 2021-10-07 | Coastal Carolina | 52 | Arkansas State | 20 | Final | L | -32 |
| 7 | 2021-10-21 | Louisiana | 28 | Arkansas State | 27 | Final | L | -1 |
| 8 | 2021-10-30 | Arkansas State | 13 | South Alabama | 31 | Final | L | -18 |
| 9 | 2021-11-06 | Appalachian State | 48 | Arkansas State | 14 | Final | L | -34 |
| 10 | 2021-11-13 | Arkansas State | 27 | Louisiana-Monroe | 24 | Final | W | 3 |
| 11 | 2021-11-20 | Arkansas State | 20 | Georgia State | 28 | Final | L | -8 |
| 12 | 2021-11-27 | Texas State (128) | 24 | Arkansas State (153) | 22 | Final | L | -2 |