Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Central Michigan | 24 | Missouri | 34 | Final | L | -10 |
| 2 | 2021-09-11 | Robert Morris | 0 | Central Michigan | 45 | Final | W | 45 |
| 3 | 2021-09-18 | Central Michigan | 21 | LSU | 49 | Final | L | -28 |
| 4 | 2021-09-25 | Florida International | 27 | Central Michigan | 31 | Final | W | 4 |
| 5 | 2021-10-02 | Central Michigan | 17 | Miami (OH) | 28 | Final | L | -11 |
| 6 | 2021-10-09 | Central Michigan | 30 | Ohio | 27 | Final | W | 3 |
| 7 | 2021-10-16 | Toledo | 23 | Central Michigan | 26 | Final(OT) | W | 3 |
| 8 | 2021-10-23 | Northern Illinois | 39 | Central Michigan | 38 | Final | L | -1 |
| 9 | 2021-11-03 | Central Michigan | 42 | Western Michigan | 30 | Final | W | 12 |
| 10 | 2021-11-10 | Kent State | 30 | Central Michigan | 54 | Final | W | 24 |
| 11 | 2021-11-17 | Central Michigan | 37 | Ball State | 17 | Final | W | 20 |
| 12 | 2021-11-26 | Eastern Michigan (83) | 10 | Central Michigan (59) | 31 | Final | W | 21 |
| 13 | 2021-12-31 | Washington State (69) | 21 | Central Michigan (60) | 24 | Final | W | 3 |
| 14 | 2021-12-31 | Central Michigan (60) | 0 | Boise State (32) | 0 | Cancelled | - | - |