Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Tennessee Tech (239) | 10 | Kansas (130) | 56 | Final | L | -46 |
| 2 | 2022-09-10 | Texas A&M-Commerce | 25 | Tennessee Tech (239) | 26 | Final | W | 1 |
| 3 | 2022-09-17 | Samford (163) | 33 | Tennessee Tech (206) | 28 | Final | L | -5 |
| 4 | 2022-10-01 | Tennessee Tech (210) | 28 | Tennessee-Martin (168) | 45 | Final | L | -17 |
| 5 | 2022-10-08 | Tennessee Tech (205) | 20 | Southeast Missouri State (131) | 34 | Final | L | -14 |
| 6 | 2022-10-15 | Tennessee State (223) | 30 | Tennessee Tech (220) | 14 | Final | L | -16 |
| 7 | 2022-10-22 | Tennessee Tech (227) | 30 | Kennesaw State (207) | 33 | Final(OT) | L | -3 |
| 8 | 2022-10-29 | Tennessee Tech (222) | 20 | Eastern Illinois (227) | 17 | Final | W | 3 |
| 9 | 2022-11-05 | Lindenwood (197) | 34 | Tennessee Tech (213) | 35 | Final | W | 1 |
| 10 | 2022-11-12 | Tennessee Tech (208) | 35 | North Alabama (249) | 27 | Final | W | 8 |
| 11 | 2022-11-19 | North Carolina Central (162) | 22 | Tennessee Tech (213) | 20 | Final | L | -2 |