Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Northern Iowa | 10 | Iowa State | 16 | Final | L | -6 |
| 2 | 2021-09-11 | Northern Iowa | 34 | Sacramento State | 16 | Final | W | 18 |
| 3 | 2021-09-18 | St. Thomas | 3 | Northern Iowa | 44 | Final | W | 41 |
| 4 | 2021-10-02 | Youngstown State | 7 | Northern Iowa | 34 | Final | W | 27 |
| 5 | 2021-10-09 | Northern Iowa | 20 | North Dakota State | 34 | Final | L | -14 |
| 6 | 2021-10-16 | South Dakota | 34 | Northern Iowa | 21 | Final | L | -13 |
| 7 | 2021-10-23 | Northern Iowa | 26 | South Dakota State | 17 | Final | W | 9 |
| 8 | 2021-10-30 | Southern Illinois | 16 | Northern Iowa | 23 | Final | W | 7 |
| 9 | 2021-11-06 | Northern Iowa | 10 | Illinois State | 17 | Final(OT) | L | -7 |
| 10 | 2021-11-13 | Northern Iowa | 27 | Missouri State | 34 | Final | L | -7 |
| 11 | 2021-11-20 | Western Illinois | 3 | Northern Iowa | 41 | Final | W | 38 |
| 12 | 2021-11-27 | Northern Iowa (142) | 9 | Eastern Washington (102) | 19 | Final | L | -10 |