Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Southern | 3 | Troy | 55 | Final | W | 52 |
| 2 | 2021-09-11 | Liberty | 21 | Troy | 13 | Final | L | -8 |
| 3 | 2021-09-18 | Troy | 21 | Southern Miss | 9 | Final | W | 12 |
| 4 | 2021-09-25 | Troy | 16 | Louisiana-Monroe | 29 | Final | L | -13 |
| 5 | 2021-10-02 | Troy | 14 | South Carolina | 23 | Final | L | -9 |
| 6 | 2021-10-09 | Georgia Southern | 24 | Troy | 27 | Final | W | 3 |
| 7 | 2021-10-16 | Troy | 31 | Texas State | 28 | Final | W | 3 |
| 8 | 2021-10-28 | Troy | 28 | Coastal Carolina | 35 | Final | L | -7 |
| 9 | 2021-11-06 | South Alabama | 24 | Troy | 31 | Final | W | 7 |
| 10 | 2021-11-13 | Louisiana | 35 | Troy | 21 | Final | L | -14 |
| 11 | 2021-11-20 | Appalachian State | 45 | Troy | 7 | Final | L | -38 |
| 12 | 2021-11-27 | Troy (103) | 10 | Georgia State (71) | 37 | Final | L | -27 |