Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Northwestern State | 14 | North Texas | 44 | Final | L | -30 |
| 2 | 2021-09-11 | Northwestern State | 10 | Alcorn State | 13 | Final | L | -3 |
| 3 | 2021-09-18 | Tennessee-Martin | 35 | Northwestern State | 10 | Final | L | -25 |
| 4 | 2021-10-02 | Incarnate Word | 38 | Northwestern State | 27 | Final | L | -11 |
| 5 | 2021-10-09 | Northwestern State | 21 | Houston Baptist | 17 | Final | W | 4 |
| 6 | 2021-10-16 | McNeese State | 35 | Northwestern State | 17 | Final | L | -18 |
| 7 | 2021-10-23 | Southeastern Louisiana | 51 | Northwestern State | 14 | Final | L | -37 |
| 8 | 2021-10-30 | Northwestern State | 21 | Nicholls State | 42 | Final | L | -21 |
| 9 | 2021-11-06 | Houston Baptist | 24 | Northwestern State | 28 | Final | W | 4 |
| 10 | 2021-11-13 | Northwestern State | 28 | Southeastern Louisiana | 56 | Final | L | -28 |
| 11 | 2021-11-20 | Northwestern State | 24 | McNeese State | 20 | Final | W | 4 |