Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Southeastern Louisiana | 49 | North Alabama | 28 | Final | L | -21 |
| 2 | 2021-09-11 | Chattanooga | 20 | North Alabama | 0 | Final | L | -20 |
| 3 | 2021-09-18 | North Alabama | 24 | Jacksonville State | 27 | Final | L | -3 |
| 4 | 2021-09-25 | North Alabama | 14 | Nicholls State | 31 | Final | L | -17 |
| 5 | 2021-10-02 | Campbell | 48 | North Alabama | 31 | Final | L | -17 |
| 6 | 2021-10-09 | North Alabama | 34 | North Carolina A&T | 38 | Final | L | -4 |
| 7 | 2021-10-16 | Robert Morris | 31 | North Alabama | 42 | Final | W | 11 |
| 8 | 2021-10-23 | Charleston Southern | 22 | North Alabama | 45 | Final | W | 23 |
| 9 | 2021-11-06 | North Alabama | 33 | Monmouth | 45 | Final | L | -12 |
| 10 | 2021-11-13 | Kennesaw State | 28 | North Alabama | 24 | Final | L | -4 |
| 11 | 2021-11-20 | North Alabama | 35 | Hampton | 27 | Final | W | 8 |