Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Houston Baptist | 17 | New Mexico | 27 | Final | L | -10 |
| 2 | 2021-09-11 | Northern Colorado | 45 | Houston Baptist | 13 | Final | L | -32 |
| 3 | 2021-09-18 | Houston Baptist | 27 | Prairie View A&M | 37 | Final | L | -10 |
| 4 | 2021-10-02 | Houston Baptist | 17 | Nicholls State | 48 | Final | L | -31 |
| 5 | 2021-10-09 | Northwestern State | 21 | Houston Baptist | 17 | Final | L | -4 |
| 6 | 2021-10-16 | Houston Baptist | 24 | Southeastern Louisiana | 61 | Final | L | -37 |
| 7 | 2021-10-23 | Nicholls State | 44 | Houston Baptist | 14 | Final | L | -30 |
| 8 | 2021-10-30 | Houston Baptist | 21 | Incarnate Word | 49 | Final | L | -28 |
| 9 | 2021-11-06 | Houston Baptist | 24 | Northwestern State | 28 | Final | L | -4 |
| 10 | 2021-11-13 | McNeese State | 44 | Houston Baptist | 3 | Final | L | -41 |
| 11 | 2021-11-20 | Incarnate Word | 55 | Houston Baptist | 14 | Final | L | -41 |