Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | South Alabama | 21 | Mississippi State | 20 | Final | W | 1 |
| 2 | 2016-09-10 | Georgia Southern | 24 | South Alabama | 9 | Final | L | -15 |
| 3 | 2016-09-17 | South Alabama | 23 | Louisiana | 28 | Final | L | -5 |
| 4 | 2016-09-24 | Nicholls State | 40 | South Alabama | 41 | Final/OT | W | 1 |
| 5 | 2016-10-01 | San Diego State (31) | 24 | South Alabama (91) | 42 | Final | W | 18 |
| 6 | 2016-10-15 | South Alabama (80) | 7 | Arkansas State (119) | 17 | Final | L | -10 |
| 7 | 2016-10-20 | Troy (17) | 28 | South Alabama (94) | 21 | Final | L | -7 |
| 8 | 2016-10-29 | Georgia State (109) | 10 | South Alabama (94) | 13 | Final | W | 3 |
| 9 | 2016-11-05 | South Alabama | 35 | Louisiana-Monroe | 42 | Final/OT | L | -7 |
| 10 | 2016-11-18 | South Alabama (95) | 0 | LSU (20) | 0 | 11/19 - TBD | - | - |
| 11 | 2016-11-19 | Presbyterian (236) | 7 | South Alabama (95) | 31 | Final | W | 24 |
| 12 | 2016-11-26 | South Alabama (94) | 31 | Idaho (73) | 38 | Final | L | -7 |
| 13 | 2016-12-03 | New Mexico State | 28 | South Alabama | 35 | Final | W | 7 |
| 14 | 2016-12-30 | South Alabama (96) | 21 | Air Force (45) | 45 | Final | L | -24 |