Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | South Alabama | 21 | Mississippi State | 20 | Final | L | -1 |
| 2 | 2016-09-10 | South Carolina | 14 | Mississippi State | 27 | Final | W | 13 |
| 3 | 2016-09-17 | Mississippi State | 20 | LSU | 23 | Final | L | -3 |
| 4 | 2016-09-24 | Mississippi State | 47 | Massachusetts | 35 | Final | W | 12 |
| 5 | 2016-10-08 | Auburn | 38 | Mississippi State | 14 | Final | L | -24 |
| 6 | 2016-10-14 | Mississippi State | 21 | BYU | 28 | Final/2OT | L | -7 |
| 7 | 2016-10-22 | Mississippi State | 38 | Kentucky | 40 | Final | L | -2 |
| 8 | 2016-10-29 | Samford | 41 | Mississippi State | 56 | Final | W | 15 |
| 9 | 2016-11-05 | Texas A&M | 28 | Mississippi State | 35 | Final | W | 7 |
| 10 | 2016-11-12 | Mississippi State | 3 | Alabama | 51 | Final | L | -48 |
| 11 | 2016-11-19 | Arkansas | 58 | Mississippi State | 42 | Final | L | -16 |
| 12 | 2016-11-26 | Mississippi State | 55 | Ole Miss | 20 | Final | W | 35 |
| 13 | 2016-12-26 | Miami (OH) | 16 | Mississippi State | 17 | Final | W | 1 |