Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-10 | Nicholls State | 24 | Georgia | 26 | Final | L | -2 |
| 2 | 2016-09-17 | Incarnate Word | 28 | Nicholls State | 35 | Final | W | 7 |
| 3 | 2016-09-24 | Nicholls State | 40 | South Alabama | 41 | Final/OT | L | -1 |
| 4 | 2016-10-01 | Nicholls State | 13 | McNeese State | 38 | Final | L | -25 |
| 5 | 2016-10-08 | Stephen F. Austin | 28 | Nicholls State | 35 | Final/2OT | W | 7 |
| 6 | 2016-10-15 | Nicholls State | 33 | Houston Baptist | 30 | Final/2OT | W | 3 |
| 7 | 2016-10-22 | Sam Houston State | 38 | Nicholls State | 21 | Final | L | -17 |
| 8 | 2016-10-29 | Nicholls State | 31 | Northwestern State | 14 | Final | W | 17 |
| 9 | 2016-11-03 | Lamar | 10 | Nicholls State | 35 | Final | W | 25 |
| 10 | 2016-11-12 | Nicholls State | 24 | Central Arkansas | 31 | Final | L | -7 |
| 11 | 2016-11-17 | Southeastern Louisiana | 44 | Nicholls State | 42 | Final | L | -2 |