Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-11 | Vanderbilt | 24 | Colorado State | 21 | Final | L | -3 |
| 2 | 2021-09-18 | Colorado State | 22 | Toledo | 6 | Final | W | 16 |
| 3 | 2021-09-25 | Colorado State | 14 | Iowa | 24 | Final | L | -10 |
| 4 | 2021-10-09 | San Jose State | 14 | Colorado State | 32 | Final | W | 18 |
| 5 | 2021-10-16 | Colorado State | 36 | New Mexico | 7 | Final | W | 29 |
| 6 | 2021-10-22 | Colorado State | 24 | Utah State | 26 | Final | L | -2 |
| 7 | 2021-10-30 | Boise State | 28 | Colorado State | 19 | Final | L | -9 |
| 8 | 2021-11-06 | Colorado State | 17 | Wyoming | 31 | Final | L | -14 |
| 9 | 2021-11-13 | Air Force | 35 | Colorado State | 21 | Final | L | -14 |
| 10 | 2021-11-20 | Colorado State | 45 | Hawaii | 50 | Final | L | -5 |
| 11 | 2021-11-27 | Nevada (39) | 52 | Colorado State (104) | 10 | Final | L | -42 |