Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Western Michigan | 14 | Michigan | 47 | Final | L | -33 |
| 2 | 2021-09-11 | Illinois State | 0 | Western Michigan | 28 | Final | W | 28 |
| 3 | 2021-09-18 | Western Michigan | 44 | Pittsburgh | 41 | Final | W | 3 |
| 4 | 2021-09-25 | San Jose State | 3 | Western Michigan | 23 | Final | W | 20 |
| 5 | 2021-10-02 | Western Michigan | 24 | Buffalo | 17 | Final | W | 7 |
| 6 | 2021-10-09 | Ball State | 45 | Western Michigan | 20 | Final | L | -25 |
| 7 | 2021-10-16 | Kent State | 31 | Western Michigan | 64 | Final | W | 33 |
| 8 | 2021-10-23 | Western Michigan | 15 | Toledo | 34 | Final | L | -19 |
| 9 | 2021-11-03 | Central Michigan | 42 | Western Michigan | 30 | Final | L | -12 |
| 10 | 2021-11-09 | Akron | 40 | Western Michigan | 45 | Final | W | 5 |
| 11 | 2021-11-16 | Western Michigan | 21 | Eastern Michigan | 22 | Final | L | -1 |
| 12 | 2021-11-23 | Western Michigan (67) | 42 | Northern Illinois (66) | 21 | Final | W | 21 |
| 13 | 2021-12-27 | Western Michigan (61) | 52 | Nevada (49) | 24 | Final | W | 28 |