Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Louisiana Tech (127) | 24 | Missouri (72) | 52 | Final | L | -28 |
| 2 | 2022-09-10 | Stephen F. Austin (148) | 17 | Louisiana Tech (127) | 52 | Final | W | 35 |
| 3 | 2022-09-17 | Louisiana Tech (114) | 20 | Clemson (27) | 48 | Final | L | -28 |
| 4 | 2022-09-24 | Louisiana Tech (116) | 14 | South Alabama (42) | 38 | Final | L | -24 |
| 5 | 2022-10-08 | UTEP (119) | 31 | Louisiana Tech (97) | 41 | Final | W | 10 |
| 6 | 2022-10-15 | Louisiana Tech (116) | 27 | North Texas (81) | 47 | Final | L | -20 |
| 7 | 2022-10-22 | Rice (72) | 42 | Louisiana Tech (116) | 41 | Final(OT) | L | -1 |
| 8 | 2022-10-28 | Louisiana Tech (127) | 34 | Florida International (122) | 42 | Final(2OT) | L | -8 |
| 9 | 2022-11-05 | Middle Tennessee (110) | 24 | Louisiana Tech (117) | 40 | Final | W | 16 |
| 10 | 2022-11-12 | Louisiana Tech (123) | 7 | UTSA (39) | 51 | Final | L | -44 |
| 11 | 2022-11-19 | Louisiana Tech (130) | 21 | Charlotte (146) | 26 | Final | L | -5 |
| 12 | 2022-11-26 | UAB (75) | 37 | Louisiana Tech (133) | 27 | Final | L | -10 |