Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Charlotte (120) | 13 | Florida Atlantic (99) | 43 | Final | L | -30 |
| 2 | 2022-09-02 | William & Mary (166) | 41 | Charlotte (120) | 24 | Final | L | -17 |
| 3 | 2022-09-10 | Maryland (48) | 56 | Charlotte (120) | 21 | Final | L | -35 |
| 4 | 2022-09-17 | Charlotte (136) | 42 | Georgia State (133) | 41 | Final | W | 1 |
| 5 | 2022-09-24 | Charlotte (153) | 20 | South Carolina (81) | 56 | Final | L | -36 |
| 6 | 2022-10-01 | UTEP (97) | 41 | Charlotte (153) | 35 | Final | L | -6 |
| 7 | 2022-10-15 | Charlotte (150) | 20 | UAB (46) | 34 | Final | L | -14 |
| 8 | 2022-10-22 | Florida International (134) | 34 | Charlotte (165) | 15 | Final | L | -19 |
| 9 | 2022-10-29 | Charlotte (138) | 56 | Rice (100) | 23 | Final | W | 33 |
| 10 | 2022-11-05 | Western Kentucky (67) | 59 | Charlotte (147) | 7 | Final | L | -52 |
| 11 | 2022-11-12 | Charlotte (154) | 14 | Middle Tennessee (103) | 24 | Final | L | -10 |
| 12 | 2022-11-19 | Louisiana Tech (130) | 21 | Charlotte (146) | 26 | Final | W | 5 |